1b6l: Difference between revisions

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[[Image:1b6l.jpg|left|200px]]<br /><applet load="1b6l" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1b6l.jpg|left|200px]]
caption="1b6l, resolution 1.75&Aring;" />
 
'''HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4'''<br />
{{Structure
|PDB= 1b6l |SIZE=350|CAPTION= <scene name='initialview01'>1b6l</scene>, resolution 1.75&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=PI4:1-[2-(8-CARBAMOYLMETHYL-6,9-DIOXO-2-OXA-7,10-DIAZA-BICYCLO[11.2.2]HEPTADECA- 1(16),13(17),14-TRIEN-11-YL)-2-HYDROXY-ETHYL]-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYLAMIDE'>PI4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1B6L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_arv2/sf2) Human immunodeficiency virus type 1 (isolate arv2/sf2)] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=PI4:'>PI4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6L OCA].  
1B6L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_arv2/sf2) Human immunodeficiency virus type 1 (isolate arv2/sf2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6L OCA].  


==Reference==
==Reference==
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease., Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC, Fairlie DP, Biochemistry. 1999 Jun 22;38(25):7978-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10387041 10387041]
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease., Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC, Fairlie DP, Biochemistry. 1999 Jun 22;38(25):7978-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10387041 10387041]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus type 1 (isolate arv2/sf2)]]
[[Category: Human immunodeficiency virus type 1 (isolate arv2/sf2)]]
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[[Category: complex (acid proteinase/peptide)]]
[[Category: complex (acid proteinase/peptide)]]


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