1b3j: Difference between revisions

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Revision as of 11:05, 20 March 2008

File:1b3j.gif

, resolution 3.00Å

Gene:

MICA-001 (Homo sapiens)

Coordinates:

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STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND

OverviewOverview

The major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of gammadelta T cells independent of beta2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain organization. The only remnant of a peptide-binding groove is a small cavity formed as the result of disordering a large section of one of the groove-defining helices. Loss of beta2-microglobulin binding is due to a restructuring of the interaction interfaces. Structural mapping of sequence variation suggests potential receptor binding sites on the underside of the platform on the side opposite of the surface recognized by alphabeta T cell receptors on MHC class I-peptide complexes.

About this StructureAbout this Structure

1B3J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:10367903

Page seeded by OCA on Thu Mar 20 10:05:48 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1b3j.gif|left|200px]]<br /><applet load="1b3j" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1b3j.gif|left|200px]]
-caption="1b3j, resolution 3.00&Aring;" />
-'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''<br />
+ {{Structure
+|PDB= 1b3j |SIZE=350|CAPTION= <scene name='initialview01'>1b3j</scene>, resolution 3.00&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= MICA-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-B3J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3J OCA].
+B3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3J OCA].
 ==Reference==
-Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10367903 10367903]
+Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10367903 10367903]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 29: / Line 38: @@
 [[Category: t-cell]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:51:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:05:48 2008''