1b2l: Difference between revisions

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[[Image:1b2l.jpg|left|200px]]<br /><applet load="1b2l" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1b2l.jpg|left|200px]]
caption="1b2l, resolution 1.6&Aring;" />
 
'''ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS: TERNARY COMPLEX WITH NAD-CYCLOHEXANONE'''<br />
{{Structure
|PDB= 1b2l |SIZE=350|CAPTION= <scene name='initialview01'>1b2l</scene>, resolution 1.6&Aring;
|SITE= <scene name='pdbsite=ACA:Catalytic+Triad'>ACA</scene>, <scene name='pdbsite=CAA:Ca2++Binding+Residues'>CAA</scene>, <scene name='pdbsite=NA1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NA1</scene>, <scene name='pdbsite=NA2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NA2</scene> and <scene name='pdbsite=NA3:Nad/Nadp+Selectivity+Amino+Acid'>NA3</scene>
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDC:NICOTINAMIDE+ADENINE+DINUCLEOTIDE+CYCLOHEXANONE'>NDC</scene>, <scene name='pdbligand=CYH:CYCLOHEXANONE'>CYH</scene> and <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]
|GENE=
}}
 
'''ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS: TERNARY COMPLEX WITH NAD-CYCLOHEXANONE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1B2L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=NDC:'>NDC</scene>, <scene name='pdbligand=CYH:'>CYH</scene> and <scene name='pdbligand=DTT:'>DTT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] Known structural/functional Sites: <scene name='pdbsite=ACA:Catalytic+Triad'>ACA</scene>, <scene name='pdbsite=CAA:Ca2++Binding+Residues'>CAA</scene>, <scene name='pdbsite=NA1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NA1</scene>, <scene name='pdbsite=NA2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NA2</scene> and <scene name='pdbsite=NA3:Nad/Nadp+Selectivity+Amino+Acid'>NA3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B2L OCA].  
1B2L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B2L OCA].  


==Reference==
==Reference==
The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1999 Jun 4;289(2):335-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10366509 10366509]
The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1999 Jun 4;289(2):335-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10366509 10366509]
[[Category: Alcohol dehydrogenase]]
[[Category: Alcohol dehydrogenase]]
[[Category: Scaptodrosophila lebanonensis]]
[[Category: Scaptodrosophila lebanonensis]]
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[[Category: nad- cyclohexanone adduct]]
[[Category: nad- cyclohexanone adduct]]
[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
[[Category: short-chain dehydrogenases/reductases]]
[[Category: short-chain dehydrogenases/reductase]]
[[Category: ternary complex]]
[[Category: ternary complex]]


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