1ath: Difference between revisions

Revision as of 11:02, 20 March 2008

, resolution 3.2Å

Coordinates:

THE INTACT AND CLEAVED HUMAN ANTITHROMBIN III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS

OverviewOverview

Antithrombin is a member of the serine proteinase inhibitor (serpin) family which contain a flexible reactive site loop that interacts with, and is cleaved by the target proteinase. In cleaved and latent serpins, the reactive site loop is inserted into a large central beta-sheet in the same molecule, whereas in ovalbumin, a nonfunctional serpin, the reactive site loop is completely exposed and in an alpha-helical conformation. However, in neither conformation can the reactive site loop bind to target proteinases. Here we report the structure of an intact and cleaved human antithrombin complex. The intact reactive site loop is in a novel conformation that seems well suited for interaction with proteinases such as thrombin and blood coagulation factor Xa.

About this StructureAbout this Structure

1ATH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions., Schreuder HA, de Boer B, Dijkema R, Mulders J, Theunissen HJ, Grootenhuis PD, Hol WG, Nat Struct Biol. 1994 Jan;1(1):48-54. PMID:7656006

Page seeded by OCA on Thu Mar 20 10:02:06 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1ath.gif|left|200px]]<br /><applet load="1ath" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ath.gif|left|200px]]
-caption="1ath, resolution 3.2&Aring;" />
-'''THE INTACT AND CLEAVED HUMAN ANTITHROMBIN III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS'''<br />
+ {{Structure
+|PDB= 1ath |SIZE=350|CAPTION= <scene name='initialview01'>1ath</scene>, resolution 3.2&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''THE INTACT AND CLEAVED HUMAN ANTITHROMBIN III COMPLEX AS A MODEL FOR SERPIN-PROTEINASE INTERACTIONS'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ATH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATH OCA].
+ATH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATH OCA].
 ==Reference==
-The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions., Schreuder HA, de Boer B, Dijkema R, Mulders J, Theunissen HJ, Grootenhuis PD, Hol WG, Nat Struct Biol. 1994 Jan;1(1):48-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656006 7656006]
+The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions., Schreuder HA, de Boer B, Dijkema R, Mulders J, Theunissen HJ, Grootenhuis PD, Hol WG, Nat Struct Biol. 1994 Jan;1(1):48-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656006 7656006]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
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 [[Category: human antithrombin-iii]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:02:06 2008''