1anp: Difference between revisions
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[[Image:1anp.gif|left|200px]] | [[Image:1anp.gif|left|200px]] | ||
'''SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR''' | {{Structure | ||
|PDB= 1anp |SIZE=350|CAPTION= <scene name='initialview01'>1anp</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ANP is a [ | 1ANP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA]. | ||
==Reference== | ==Reference== | ||
Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor., Fairbrother WJ, McDowell RS, Cunningham BC, Biochemistry. 1994 Aug 2;33(30):8897-904. PMID:[http:// | Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor., Fairbrother WJ, McDowell RS, Cunningham BC, Biochemistry. 1994 Aug 2;33(30):8897-904. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8043577 8043577] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hypotensive hormone]] | [[Category: hypotensive hormone]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:59:58 2008'' | ||
Revision as of 10:59, 20 March 2008
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| Gene: | POTENTIAL (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR
OverviewOverview
Two-dimensional NMR spectroscopy has been used to characterize the solution conformation of an atrial natriuretic peptide (ANP) variant which is selective for the human natriuretic peptide receptor A (NPR-A) relative to receptor C (NPR-C). The ANP mutant, containing six substitutions, has reduced flexibility in aqueous solution relative to wild-type ANP and allows the observation of sufficient NOE connectivities for structure determination by distance geometry and restrained molecular dynamics calculations. The solution conformation is reasonably well defined, having an average backbone atom rms deviation from the average coordinates of approximately 1.1 A for residues 7-27. The structure is consistent with available functional data and shows a spatial separation between known receptor binding determinants and residues found to be outside the hormone-receptor interface.
DiseaseDisease
Known disease associated with this structure: Acromesomelic dysplasia, Maroteaux type OMIM:[108961]
About this StructureAbout this Structure
1ANP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor., Fairbrother WJ, McDowell RS, Cunningham BC, Biochemistry. 1994 Aug 2;33(30):8897-904. PMID:8043577
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