1ad5: Difference between revisions

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Revision as of 10:56, 20 March 2008

File:1ad5.jpg

, resolution 2.6Å

Ligands:

and

Gene:

HUMAN HCK (Homo sapiens)

Activity:

Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2

Coordinates:

save as pdb, mmCIF, xml

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

OverviewOverview

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

About this StructureAbout this Structure

1AD5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658

Page seeded by OCA on Thu Mar 20 09:55:59 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ad5.jpg|left|200px]]<br /><applet load="1ad5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ad5.jpg|left|200px]]
-caption="1ad5, resolution 2.6&Aring;" />
-'''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''<br />
+ {{Structure
+|PDB= 1ad5 |SIZE=350|CAPTION= <scene name='initialview01'>1ad5</scene>, resolution 2.6&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
+|GENE= HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''SRC FAMILY KINASE HCK-AMP-PNP COMPLEX'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-AD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD5 OCA].
+AD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD5 OCA].
 ==Reference==
-Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9024658 9024658]
+Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9024658 9024658]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 26: / Line 35: @@
 [[Category: tyrosine-protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:59 2008''