P53-DNA Recognition: Difference between revisions

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==Tetramerization Domain==
==Tetramerization Domain==
<Structure load='P53tetra.pdb.zip' size='250' frame='true' align='left' caption='Figure 5: Crystal structure of p53 tetramerization domain, [http://proteopedia.com/wiki/index.php/1c26 PDB ID 1C26].' scene='Sandbox_Reserved_170/Tetra/2' />
<Structure load='P53tetra.pdb.zip' size='250' frame='true' align='right' caption='Figure 7: Crystal structure of p53 tetramerization domain, [http://proteopedia.com/wiki/index.php/1c26 PDB ID 1C26].' scene='Sandbox_Reserved_170/Tetra/2' />
 
Aside from the DBD, the only other domain for which structural information is available is the ''tetramerization domain'' ['''Figure 5''', <scene name='Sandbox_Reserved_170/Tetra/2'>restore initial scene</scene>], which forms as a dimer of dimers with one alpha helix and one beta strand contributed by each p53 monomer. The tetramerization domain is ''not present'' in the crystal structure of the DBD (Figure 4).


Aside from the DBD, the only other domain for which structural information is available is the ''tetramerization domain'' ['''Figure 7''', <scene name='Sandbox_Reserved_170/Tetra/2'>restore initial scene</scene>], which forms as a dimer of dimers with one alpha helix and one beta strand contributed by each p53 monomer. The tetramerization domain is ''not present'' in the crystal structure of the DBD (Figure 4).


=Further Reading=
=Further Reading=