P53-DNA Recognition: Difference between revisions
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==Introduction and Biological Role of the Tumor Suppressor p53== | ==Introduction and Biological Role of the Tumor Suppressor p53== | ||
[[Image:p53-intro.jpg|thumb|left|300px|Figure 1: Crystal structure of a p53 DBD tetramer-DNA complex; [http://www. | [[Image:p53-intro.jpg|thumb|left|300px|Figure 1: Crystal structure of a p53 DBD tetramer-DNA complex; [http://www.proteopedia.org/wiki/index.php/3kz8 PDB ID# 3KZ8]<ref name='kitayner'>Kitayner M, Rozenberg H, Rohs R, Suad O, Rabinovich D, Honig B, Shakked Z. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. Nat Struct Mol Biol. 2010;17(4):423-9.</ref>.]] | ||
[[Image:consensus.jpg|thumb|right|250px|Figure 2: p53 consensus site; R= A or G, Y= C or T, and W=A or T.]] | [[Image:consensus.jpg|thumb|right|250px|Figure 2: p53 consensus site; R= A or G, Y= C or T, and W=A or T.]] | ||