Villin: Difference between revisions

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== 3D Structures of Villin ==
== 3D Structures of Villin ==


''Update July 2012''
''Update February 2013''




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=== Villin ===
=== Villin ===


[[3fg7]] – hVIL gelsolin domains 4-6<br />  
[[3fg7]] – hVIL gelsolin domains 4-6<br />
[[2llf]] - hVIL gelsolin-like domain 6 - NMR<br />
[[1unc]] – hVIL headpiece<br />
[[1unc]] – hVIL headpiece<br />
[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br />
[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br />

Revision as of 14:14, 14 February 2013

File:2k6n.png
Crystal Strcture of the Human Supervillin Headpiece, 2k6n

Template:STRUCTURE 2k6n


















Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).


3D Structures of Villin3D Structures of Villin

Update February 2013


SupervillinSupervillin

2k6m, 2k6n – hSVIL headpiece– human – NMR

VillinVillin

3fg7 – hVIL gelsolin domains 4-6
2llf - hVIL gelsolin-like domain 6 - NMR
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic

AdvillinAdvillin

1und – hAVIL headpiece

ReferencesReferences

  1. Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman