1ob7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[ | ==Cephaibol C== | ||
<StructureSection load='1ob7' size='340' side='right' caption='[[1ob7]], [[Resolution|resolution]] 0.89Å' scene=''> | |||
== Structural highlights == | |||
[[1ob7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acremonium_tubakii Acremonium tubakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB7 OCA]. <br> | |||
<b>Related:</b> [[1m24|1m24]], [[1r9u|1r9u]], [[1dlz|1dlz]], [[1ih9|1ih9]], [[1gq0|1gq0]], [[1joh|1joh]], [[1amt|1amt]], [[1ee7|1ee7]], [[1ob6|1ob6]], [[1ob4|1ob4]]<br> | |||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |||
== Publication Abstract from PubMed == | |||
The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function. | |||
Crystal structures of cephaibols.,Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:14658793<ref>PMID:14658793</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Acremonium tubakii]] | [[Category: Acremonium tubakii]] | ||
[[Category: Bunkoczi, G.]] | [[Category: Bunkoczi, G.]] | ||
Revision as of 11:32, 30 April 2014
Cephaibol CCephaibol C
Structural highlights1ob7 is a 1 chain structure with sequence from Acremonium tubakii. Full crystallographic information is available from OCA. Related: 1m24, 1r9u, 1dlz, 1ih9, 1gq0, 1joh, 1amt, 1ee7, 1ob6, 1ob4 Publication Abstract from PubMedThe crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function. Crystal structures of cephaibols.,Bunkoczi G, Schiell M, Vertesy L, Sheldrick GM J Pept Sci. 2003 Nov-Dec;9(11-12):745-52. PMID:14658793[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||