2j05: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 ==Overview==
-X-ray structures of two crystal forms of the Src homology 3 domain (SH3), of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and, 1.8A resolution. The overall structure comprises a single domain with two, tightly packed beta-sheets linked by a short helical segment. An important, motif for peptide binding in other SH3 domains is not conserved in RasGAP., The RasGAP SH3 domain forms dimers in the crystal structures, which may, provide new functional insight. The dimer interface involves residues also, present in a peptide previously identified as an apoptotic sensitizer of, tumor cells.
+X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.
 ==Disease==
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 [[Category: src homology 3]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:36:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:54 2008''