Nitric Oxide Synthase: Difference between revisions
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[[Image:2g6h.png|left|200px|thumb|Crystal Structure of nitric oxide synthase, [[2g6h]]]] | [[Image:2g6h.png|left|200px|thumb|Crystal Structure of nitric oxide synthase, [[2g6h]]]] | ||
{{STRUCTURE_2g6h| PDB=2g6h | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase complex with cofactor tetrahydrobiopterin, acetate and Zn, [[2g6h]] }} | {{STRUCTURE_2g6h| PDB=2g6h | SIZE=400| SCENE=Nitric_oxide_synthase/Nos/1 |right|CAPTION=Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn, [[2g6h]] }} | ||
'''Nitric Oxide Synthase''' (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an oxygenase domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. | '''Nitric Oxide Synthase''' (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an oxygenase domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. | ||