4dm9: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:4dm9.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_4dm9", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_4dm9|  PDB=4dm9  |  SCENE=  }}
 ===The Crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide fluoromethyl ketone Z-VAE(OMe)-FMK===
+{{ABSTRACT_PUBMED_22617491}}
+==Disease==
+[[http://www.uniprot.org/uniprot/UCHL1_HUMAN UCHL1_HUMAN]] Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:[http://omim.org/entry/613643 613643]]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.<ref>PMID:12408865</ref><ref>PMID:9774100</ref><ref>PMID:12705903</ref><ref>PMID:16450370</ref>
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22617491}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/UCHL1_HUMAN UCHL1_HUMAN]] Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.<ref>PMID:9790970</ref><ref>PMID:12408865</ref><ref>PMID:18411255</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22617491 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22617491}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:022617491</ref><references group="xtra"/>
+<ref group="xtra">PMID:022617491</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Chaney, J.]]