Caspase: Difference between revisions

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Michal Harel, Alexander Berchansky

Revision as of 13:57, 4 June 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 13:55, 25 October 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	{{STRUCTURE_3d6f\| PDB=3d6f \| SIZE=400\| SCENE= \|right\| CAPTION=CASP-1 complex with polypeptide inhibitor, benzyl chlorocarbonate and fluoro methane, [[3d6f]] }}		{{STRUCTURE_3d6f\| PDB=3d6f \| SIZE=400\| SCENE= \|right\| CAPTION=CASP-1 subunit P20 (grey) and subunit P10 (green) complex with polypeptide inhibitor, benzyl chlorocarbonate and fluoro methane, [[3d6f]] }}

	'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.		'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.