1shc: Difference between revisions
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==Overview== | ==Overview== | ||
The nuclear magnetic resonance structure of the phosphotyrosine binding | The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization. | ||
==Disease== | ==Disease== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Burakoff, S | [[Category: Burakoff, S J.]] | ||
[[Category: Fesik, S | [[Category: Fesik, S W.]] | ||
[[Category: Harlan, J | [[Category: Harlan, J E.]] | ||
[[Category: Meadows, R | [[Category: Meadows, R P.]] | ||
[[Category: Olejniczak, E | [[Category: Olejniczak, E T.]] | ||
[[Category: Petros, A | [[Category: Petros, A M.]] | ||
[[Category: Ravichandran, K | [[Category: Ravichandran, K S.]] | ||
[[Category: Sattler, M.]] | [[Category: Sattler, M.]] | ||
[[Category: Wade, W | [[Category: Wade, W S.]] | ||
[[Category: Zhou, M | [[Category: Zhou, M M.]] | ||
[[Category: complex (signal transduction/peptide)]] | [[Category: complex (signal transduction/peptide)]] | ||
[[Category: phosphotyrosine binding domain (ptb)]] | [[Category: phosphotyrosine binding domain (ptb)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:01:35 2008'' | ||