3udy: Difference between revisions

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[[Image:3udy.jpg|left|200px]]
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===Crystal Structure of BACE with Compound 11===
===Crystal Structure of BACE with Compound 11===
{{ABSTRACT_PUBMED_22468999}}


 
==Function==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
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{{ABSTRACT_PUBMED_22468999}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:022468999</ref><ref group="xtra">PMID:018289105</ref><references group="xtra"/>
<ref group="xtra">PMID:022468999</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]

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