1k2p: Difference between revisions
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==Overview== | ==Overview== | ||
Bruton's tyrosine kinase is intimately involved in signal transduction | Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided. | ||
==Disease== | ==Disease== | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Mao, C.]] | [[Category: Mao, C.]] | ||
[[Category: Uckun, F | [[Category: Uckun, F M.]] | ||
[[Category: Zhou, M.]] | [[Category: Zhou, M.]] | ||
[[Category: bruton tryosine kinase]] | [[Category: bruton tryosine kinase]] | ||
[[Category: kinase domain]] | [[Category: kinase domain]] | ||
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Revision as of 14:29, 21 February 2008
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Crystal structure of Bruton's tyrosine kinase domain
OverviewOverview
Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided.
DiseaseDisease
Known diseases associated with this structure: Agammaglobulinemia, type 1, X-linked OMIM:[300300], XLA and isolated growth hormone deficiency OMIM:[300300]
About this StructureAbout this Structure
1K2P is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia., Mao C, Zhou M, Uckun FM, J Biol Chem. 2001 Nov 2;276(44):41435-43. Epub 2001 Aug 29. PMID:11527964
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