DNA: Difference between revisions

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Ala Jelani, Eran Hodis, Eric Martz, Joel L. Sussman, Adithya Sagar, Wayne Decatur, David Canner, Angel Herraez, Frédéric Dardel, Karl Oberholser, Joseph M. Steinberger, Alexander Berchansky, Ann Taylor, Karsten Theis

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 === Grooves ===
-In a <scene name='DNA/Bdnasf/1'>DNA double helix</scene> the <scene name='DNA/Angled_gylcosidic/5'>beta-glycosyl bonds</scene> of bases which are paired <scene name='DNA/Angled_gylcosidic/6'>do not lie opposite</scene> to each other but are positioned at an angle. This results in unequally spaced sugar-phosphate backbones and gives rise to two grooves: the
+In a <scene name='DNA/Bdnasf/1'>DNA double helix</scene> the <scene name='DNA/Angled_gylcosidic/5'>beta-glycosyl bonds</scene> of bases which are paired <scene name='DNA/Angled_gylcosidic/7'>do not lie opposite</scene> to each other but are positioned at an angle. This results in unequally spaced sugar-phosphate backbones and gives rise to two grooves: the
 <scene name='DNA/Major_groove/2'>major groove</scene> and the <scene name='DNA/Major_groove/4'>minor groove</scene> of different width and depth. The <scene name='DNA/Major_groove/6'>oxygen atoms of the furanose rings</scene> are on the surface of the minor groove, and the major groove is on the opposite side. The floor or surface of major groove is filled with the <scene name='DNA/Major_floor/2'>atoms of the bases</scene>. The larger size of major groove allows for the binding of DNA specific  proteins.<ref name="Saenger"> Saenger, Wolfram (1984). ''Principles of Nucleic Acid Structure '' (1st ed). Springer-Verlag. pp. 398. ISBN 0-12-645750-6.</ref><ref name='Watson'> Watson, James D, Nancy H. Hopkins, Jeffrey W. Roberts, Joan Argetsinger Steitz, Alan M.Weiner ''Molecular Biology of Gene'' (4th ed.). The Benjamin/Cummings Publishing Company Inc.pp. 239-249. ISBN 0-8053-9612-8</ref>