1hac: Difference between revisions
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==Overview== | ==Overview== | ||
Hemoglobin has been a long-standing paradigm for understanding protein | Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here, the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, alpha2beta82CA82beta and alpha2beta82ND82beta, are described at 2.3 A and 2.6 A resolution, respectively. Strikingly, these crosslinked hemoglobins assume intermediate conformations that lie between those of R and the controversial liganded hemoglobin state R2 rather than between R and T. Thus, these structures support only a T left and right arrow R left and right arrow R2 allosteric pathway and underscore the physiological importance of the R2 conformation. | ||
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brennan, R | [[Category: Brennan, R G.]] | ||
[[Category: Dixon, M | [[Category: Dixon, M M.]] | ||
[[Category: Jones, R | [[Category: Jones, R T.]] | ||
[[Category: Kluger, R.]] | [[Category: Kluger, R.]] | ||
[[Category: Schumacher, M | [[Category: Schumacher, M A.]] | ||
[[Category: CMO]] | [[Category: CMO]] | ||
[[Category: HEM]] | [[Category: HEM]] | ||
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[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:13 2008'' | ||