Reverse transcriptase: Difference between revisions
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[[Image:1hmv1.png|left|200px|thumb|Crystal Structure of unliganded HIV-1 Reverse transcriptase, [[1hmv]]]] | [[Image:1hmv1.png|left|200px|thumb|Crystal Structure of unliganded HIV-1 Reverse transcriptase, [[1hmv]]]] | ||
{{STRUCTURE_1hmv| PDB=1hmv | SIZE=400| SCENE=Reverse_transcriptase/Cv/1 |right|CAPTION=HIV-1 Reverse transcriptase, [[1hmv]] }} | {{STRUCTURE_1hmv| PDB=1hmv | SIZE=400| SCENE=Reverse_transcriptase/Cv/1 |right|CAPTION=HIV-1 Reverse transcriptase, [[1hmv]] }} | ||
[[Reverse transcriptase]] (RT) or RNA-dependent DNA polymerase transcribes single-stranded RNA into double-stranded [[DNA]]. HIV-1 RT is from the human immunodeficiency virus and is a heterodimer of P66 and P51 subchains. The images at the left and at the right correspond to one representative RT structure, ''i.e.'' crystal structure of HIV-1 Reverse transcriptase ([[1hmv]]). There are more details on HIV-1 RT in [[Phl p 2]]. P15 is its RNAse H domain. There are two types of inhibitors for RT: NNRTIs are the non-nucleoside inhibitors, and NRTIs are the nucleoide inhibitors. Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, along with [[Hiv protease|Protease]] and Integrase, the most important part of the protein system involved in the process of infection and reproduction for viruses like HIV, MuLV and AMV. RT has the unusual property of transcribing ssRNA into dsDNA going against the Central Dogma of Molecular Biology. | [[Reverse transcriptase]] (RT) or RNA-dependent DNA polymerase transcribes single-stranded RNA into double-stranded [[DNA]]. HIV-1 RT is from the human immunodeficiency virus and is a heterodimer of P66 and P51 subchains. The images at the left and at the right correspond to one representative RT structure, ''i.e.'' crystal structure of HIV-1 Reverse transcriptase ([[1hmv]]). There are more details on HIV-1 RT in [[Phl p 2]]. P15 is its RNAse H domain. There are two types of inhibitors for RT: NNRTIs are the non-nucleoside inhibitors, and NRTIs are the nucleoide inhibitors. Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, along with [[Hiv protease|Protease]] and Integrase, the most important part of the protein system involved in the process of infection and reproduction for viruses like HIV, MuLV and AMV. RT has the unusual property of transcribing ssRNA into dsDNA going against the Central Dogma of Molecular Biology. | ||