4dkt: Difference between revisions

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 {{STRUCTURE_4dkt|  PDB=4dkt  |  SCENE=  }}
 ===Crystal structure of human peptidylarginine deiminase 4 in complex with N-acetyl-L-threonyl-L-alpha-aspartyl-N5-[(1E)-2-fluoroethanimidoyl]-L-ornithinamide===
+{{ABSTRACT_PUBMED_22004374}}
+==Disease==
+[[http://www.uniprot.org/uniprot/PADI4_HUMAN PADI4_HUMAN]] Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:[http://omim.org/entry/180300 180300]]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.<ref>PMID:12833157</ref>
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+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22004374}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/PADI4_HUMAN PADI4_HUMAN]] Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.<ref>PMID:15339660</ref><ref>PMID:15345777</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22004374 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_22004374}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:022004374</ref><references group="xtra"/>
+<ref group="xtra">PMID:022004374</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Protein-arginine deiminase]]