2i6z: Difference between revisions

Revision as of 18:49, 21 February 2008

X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

OverviewOverview

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.

About this StructureAbout this Structure

2I6Z is a Single protein structure of sequence from Gallus gallus with , and as ligands. Active as Lysozyme, with EC number 3.2.1.17 Known structural/functional Sites: , and . Full crystallographic information is available from OCA.

ReferenceReference

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231

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 ==Overview==
-The interactions of cisplatin and its analogues, transplatin, carboplatin, and oxaliplatin, with hen egg white lysozyme were analysed through ESI, mass spectrometry, and the resulting metallodrug-protein adducts, identified; the X-ray crystal structure of the cisplatin lysozyme, derivative, solved at 1.9 A resolution, reveals selective platination of, imidazole Nepsilon of His15.
+The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.
 ==About this Structure==
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 [[Category: hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:17:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:46 2008''