4djy: Difference between revisions
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[[Image:4djy.jpg|left|200px]] | |||
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{{STRUCTURE_4djy| PDB=4djy | SCENE= }} | |||
===Structure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one=== | |||
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{{ABSTRACT_PUBMED_22390835}} | |||
==About this Structure== | |||
[[4djy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DJY OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022390835</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | |||
[[Category: Cumming, J.]] | |||
[[Category: Strickland, C.]] | |||
[[Category: Alzheimer]] | |||
[[Category: Bace1]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 10:32, 21 March 2012
Structure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-oneStructure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one
Template:ABSTRACT PUBMED 22390835
About this StructureAbout this Structure
4djy is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Cumming JN, Smith EM, Wang L, Misiaszek J, Durkin J, Pan J, Iserloh U, Wu Y, Zhu Z, Strickland C, Voigt J, Chen X, Kennedy ME, Kuvelkar R, Hyde LA, Cox K, Favreau L, Czarniecki MF, Greenlee WJ, McKittrick BA, Parker EM, Stamford AW. Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2444-9. Epub 2012 Feb 16. PMID:22390835 doi:10.1016/j.bmcl.2012.02.013