Caspase: Difference between revisions
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{{STRUCTURE_3d6f| PDB=3d6f | SIZE=400| SCENE= |right| CAPTION=CASP-1 complex with polypeptide inhibitor, benzyl chlorocarbonate and fluoro methane, [[3d6f]] }} | {{STRUCTURE_3d6f| PDB=3d6f | SIZE=400| SCENE= |right| CAPTION=CASP-1 complex with polypeptide inhibitor, benzyl chlorocarbonate and fluoro methane, [[3d6f]] }} | ||
'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. | '''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in Drosophila melanogaster. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
==3D structures of caspase== | ==3D structures of caspase== | ||
''Update | ''Update June 2012'' | ||
===CASP-1=== | ===CASP-1=== | ||
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[[1qx3]] - hCASP<br /> | [[1qx3]] - hCASP<br /> | ||
[[2xyg]], [[2xyh]], [[2xyp]] – hCASP subunits P12, P17 + inhibitor< | [[2xyg]], [[2xyh]], [[2xyp]] – hCASP subunits P12, P17 + inhibitor<br /> | ||
[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br /> | |||
[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[[[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br /> | [[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[[[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br /> | ||
[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br /> | [[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
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[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | [[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | ||
[[3nkf]], [[3nr2]] – hCASP (mutant) <br /> | [[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]] – hCASP (mutant) <br /> | ||
[[3od5]], [[3p4u]], [[3qnw]] – hCASP + polypeptide inhibitor<br /> | [[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br /> | ||
===CASP-7=== | ===CASP-7=== | ||
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[[3ygs]] – hpro-CASP + APAF-1 CARD | [[3ygs]] – hpro-CASP + APAF-1 CARD | ||
===Drosophila melanogaster CASP=== | |||
[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br /> | |||
[[3sir]] - DmCASP drICE residues 78-332<br /> | |||
[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br /> | |||
===Metacaspase=== | |||
[[4afp]], [[4afr]], [[4afv]] – MCASP (mutant) – ''Trypanosom brucei'' | |||