4a57: Difference between revisions

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[[Image:4a57.png|left|200px]]
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{{STRUCTURE_4a57|  PDB=4a57  |  SCENE=  }}  
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===CRYSTAL STRUCTURE OF TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 (NTPDASE3)===
===CRYSTAL STRUCTURE OF TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 (NTPDASE3)===
{{ABSTRACT_PUBMED_22130673}}


 
==Function==
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[[http://www.uniprot.org/uniprot/NTP1_TOXGO NTP1_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite and may contribute to intracellular survival and virulence. NTPAse-I has a specific activity 4.5-fold higher than NTPAse-II in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
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{{ABSTRACT_PUBMED_22130673}}


==About this Structure==
==About this Structure==
[[4a57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A57 OCA].  
[[4a57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A57 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:022130673</ref><references group="xtra"/>
<ref group="xtra">PMID:022130673</ref><references group="xtra"/><references/>
[[Category: Nucleoside-triphosphatase]]
[[Category: Nucleoside-triphosphatase]]
[[Category: Toxoplasma gondii]]
[[Category: Toxgo]]
[[Category: Krug, U.]]
[[Category: Krug, U.]]
[[Category: Straeter, N.]]
[[Category: Straeter, N.]]
[[Category: Zebisch, M.]]
[[Category: Zebisch, M.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Ntpdase]]

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