Sandbox 27: Difference between revisions
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PLEASE do NOT change this sandbox. It is currently reserved for a Proteopedia Project (ESBS Strasbourg) | ''PLEASE do NOT change this sandbox. It is currently reserved for a Proteopedia Project (ESBS Strasbourg)'' | ||
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== TSH and M22== | == TSH and M22== | ||
TSH is a hormone also known as "thyrotropin". It is a member of the Glycoprotein Hormone Family or GHF(like hormones LH, FSH or hCG). TSH regulates the growth and the function of thyroid follicular cells by stimulating the secretion of thyroid hormones T3 and T4. These play an important role in human reproduction, metabolism and cellular development. Therefore, this class of receptors is central to medical, pharmaceutical, and biological research. | TSH is a hormone also known as "thyrotropin". It is a member of the Glycoprotein Hormone Family or GHF(like hormones LH, FSH or hCG). TSH regulates the growth and the function of thyroid follicular cells by stimulating the secretion of thyroid hormones T3 and T4. These play an important role in human reproduction, metabolism and cellular development. Therefore, this class of receptors is central to medical, pharmaceutical, and biological research. | ||
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M22 is a thyroid stimulating human monoclonal antibody prepared using lymphocytes from a patient with Graves’ disease. It is an antibody to the TSHR. It mimics closely the binding of TSH on its receptor, so it stimulates the receptor and inhibits the binding of TSH to give rise to full activation of receptor mediated signal transduction. | M22 is a thyroid stimulating human monoclonal antibody prepared using lymphocytes from a patient with Graves’ disease. It is an antibody to the TSHR. It mimics closely the binding of TSH on its receptor, so it stimulates the receptor and inhibits the binding of TSH to give rise to full activation of receptor mediated signal transduction. | ||
== Signalling pathway == | == Signalling pathway == | ||
[[Image:TSHR 1.jpg | thumb | right]] | |||
TSH hormone or in our case the autoantibody M22 binds to its receptor (more precisely to LRD). This binding actives the receptor and then small G-proteins coupled to the receptor. The alpha subunit stimulates enzymes of the cellular membrane. A cascade of reactions and second messengers pathways are involved and result in the stimulation and the synthesis of thyroid hormones T3 and T4. | |||
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== Structure of the TSH Receptor == | == Structure of the TSH Receptor == | ||