Sandbox 215: Difference between revisions
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==Structure== | ==Structure== | ||
<Structure load='2obd' size='400' frame='true' align='left' caption='Structure of cholesteryl ester transfer protein' scene='Insert optional scene name here' />2OBD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo Sapiens]. Full crystallographic information is available from [http://www.ebi.ac.uk/msd-srv/oca/oca-bin/ocashort?id=2OBD OCA] | <Structure load='2obd' size='400' frame='true' align='left' caption='Structure of cholesteryl ester transfer protein' scene='Insert optional scene name here' (PDB entry [[2obd]])'/>2OBD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo Sapiens]. Full crystallographic information is available from [http://www.ebi.ac.uk/msd-srv/oca/oca-bin/ocashort?id=2OBD OCA] | ||
==='''Overview of the structure'''=== | ==='''Overview of the structure'''=== | ||
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CETP is constitued of four structural units: <ref>Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP. Crystal Structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nature Structural & Molecular Biology. 2007 Feb;14(2):106-13. Epub 2007 Jan 21. [http://www.ncbi.nlm.nih.gov/pubmed?term=17237796. PMID: 17237796] [http://www.nature.com.scd-rproxy.u-strasbg.fr/nsmb/journal/v14/n2/full/nsmb1197.html doi:10.1038/nsmb1197]</ref> | CETP is constitued of four structural units: <ref>Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP. Crystal Structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nature Structural & Molecular Biology. 2007 Feb;14(2):106-13. Epub 2007 Jan 21. [http://www.ncbi.nlm.nih.gov/pubmed?term=17237796. PMID: 17237796] [http://www.nature.com.scd-rproxy.u-strasbg.fr/nsmb/journal/v14/n2/full/nsmb1197.html doi:10.1038/nsmb1197]</ref> | ||
* At each end of the protein there is a barrel, which is constitued of a highly twisted ß-sheet and two helices called A and B at the <scene name='Sandbox_215/N-terminal/2'>N-terminal extremity</scene> and A', B' at C-terminal extremity. Helices B and B' are longer than helices A and A'. | * At each end of the protein there is a barrel, which is constitued of a highly twisted ß-sheet and two helices called A and B at the <scene name='Sandbox_215/N-terminal/2'>N-terminal extremity</scene> and A', B' at C-terminal extremity. Helices B and B' are longer than helices A and A'. | ||