2ccu: Difference between revisions
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==Overview== | ==Overview== | ||
Novel piperazinyl, morpholino and piperidyl derivatives of the | Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain of human Hsp90. Key features of the binding mode are essentially identical to the recently reported potent analogue VER-49009. The most potent of the new compounds has a methylsulfonylbenzyl substituent appended to the piperazine nitrogen, possesses an IC50 of less than 600 nM binding against the enzyme and demonstrates low micromolar inhibition of tumour cell proliferation. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barril, X.]] | [[Category: Barril, X.]] | ||
[[Category: Beswick, M | [[Category: Beswick, M C.]] | ||
[[Category: Collier, A.]] | [[Category: Collier, A.]] | ||
[[Category: Drysdale, M | [[Category: Drysdale, M J.]] | ||
[[Category: Dymock, B | [[Category: Dymock, B W.]] | ||
[[Category: Fink, A.]] | [[Category: Fink, A.]] | ||
[[Category: Grant, K.]] | [[Category: Grant, K.]] | ||
[[Category: Howes, R.]] | [[Category: Howes, R.]] | ||
[[Category: Jordan, A | [[Category: Jordan, A M.]] | ||
[[Category: Massey, A.]] | [[Category: Massey, A.]] | ||
[[Category: Surgenor, A.]] | [[Category: Surgenor, A.]] | ||
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[[Category: pyrazole]] | [[Category: pyrazole]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:47:30 2008'' | ||