User:Ketan Mathavan/Sandbox 1: Difference between revisions

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~~[[Image:intactModelLargeText.jpg|~~frame~~|Bacterial chemotaxis receptor]]~~

Test <Structure load='1UM8' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />

Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the motors that rotate the flagella ~~to cause~~ the cell to ~~either~~ continue swimming or to tumble. When an attractant molecule binds, it signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense ~~decreasing concentrations of~~ attractant molecules: "Time to tumble and try a new swimming direction."

[['''Bold text'''Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the direction of rotation of the motors that rotate the flagella. One direction causes the cell to continue swimming; the other direction causes the cell to tumble. When an attractant molecule binds, the receptor signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense a repellant or less attractant molecules: "Time to tumble and try a new swimming direction."

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Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.

Molecular Playground banner: A bacterial chemotaxis receptor protein used by bacteria to "smell" their environment.

<applet load='2ho9' size='[450,338]' frame='true' align='right'

caption='E. coli chemotaxis adaptor protein CheW (2ho9)' scene='User:Shiela_M._Jones/Sandbox_1/Chew_suppressionmutants/1'/>

=== Chemotaxis adaptor protein CheW ===

CheW is a chemotaxis adaptor protein, and part of the tertiary complex formed by the chemotaxis receptor, histidine kinase protein CheA, and CheW. As an adaptor protein, CheW mediates the interaction between the chemotaxis receptor and CheA, and is necessary for the formation of kinase active complexes. CheW has been found to bind to the P5 domain of CheA through crystallographic studies.

At right, CheW is shown with suppression mutants (blue)that have been measured to decrease receptor binding and chemotaxis (SMJ).

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-[[Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]
+Test <Structure load='1UM8' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
-Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the motors that rotate the flagella to cause the cell to either continue swimming or to tumble. When an attractant molecule binds, it signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense decreasing concentrations of attractant molecules: "Time to tumble and try a new swimming direction."
+<Structure load='1UM8' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
+[['''Bold text'''Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]
+One of the [[CBI Molecules]] being studied in the  [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
+Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the direction of rotation of the motors that rotate the flagella. One direction causes the cell to continue swimming; the other direction causes the cell to tumble. When an attractant molecule binds, the receptor signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense a repellant or less attractant molecules: "Time to tumble and try a new swimming direction."
@@ Line 17: / Line 25: @@
-Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.
+Molecular Playground banner: A bacterial chemotaxis receptor protein used by bacteria to "smell" their environment.
+{{Clear}}
+<applet load='2ho9' size='[450,338]' frame='true' align='right'
+caption='E. coli chemotaxis adaptor protein CheW (2ho9)' scene='User:Shiela_M._Jones/Sandbox_1/Chew_suppressionmutants/1'/>
+=== Chemotaxis adaptor protein CheW ===
+CheW is a chemotaxis adaptor protein, and part of the tertiary complex formed by the chemotaxis receptor, histidine kinase protein CheA, and CheW.  As an adaptor protein, CheW mediates the interaction between the chemotaxis receptor and CheA, and is necessary for the formation of kinase active complexes.  CheW has been found to bind to the P5 domain of CheA through crystallographic studies.
+At right, CheW is shown with suppression mutants (blue)that have been measured to decrease receptor binding and chemotaxis (SMJ).