Human Caspase-1: Difference between revisions
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==Structure== | ==Structure== | ||
Caspase-1 consists of four subunits, two <scene name='Human_Caspase-1/Alpha_subunit/1'>20kDa (alpha)</scene> and two <scene name='Human_Caspase-1/Beta_subunit/1'>10kDa (beta)</scene> pieces, joining to make a homodimer. It has two active sites, which can be linked as is the case with caspase-1. The large alpha subunit contains the proteolytic dyad residues <scene name='Human_Caspase-1/Cys285_and_his_237/1'>Cys285 and His237</scene>, while the smaller subunit contains residues that form a groove for ligand binding. A '<scene name='Human_Caspase-1/Asp_socket/ | Caspase-1 consists of four subunits, two <scene name='Human_Caspase-1/Alpha_subunit/1'>20kDa (alpha)</scene> and two <scene name='Human_Caspase-1/Beta_subunit/1'>10kDa (beta)</scene> pieces, joining to make a homodimer. It has two active sites, which can be linked as is the case with caspase-1. The large alpha subunit contains the proteolytic dyad residues <scene name='Human_Caspase-1/Cys285_and_his_237/1'>Cys285 and His237</scene>, while the smaller subunit contains residues that form a groove for ligand binding. A '<scene name='Human_Caspase-1/Asp_socket/2'>socket</scene>' composed of Arg179, Gln283, and Arg341 holds the carboxylate side chain of the Asp residue tightly in place. | ||
==Function== | ==Function== | ||