Anthrax Lethal Factor: Difference between revisions
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==Structure of Lethal Factor== | ==Structure of Lethal Factor== | ||
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Anthrax Lethal Factor is composed of four domains: | |||
'''Domain I''' functions in the binding of Lethal Factor to Protective Antigen 63 (PA63), which is the membrane translocation component of Anthrax Toxin. The actual location where domain I interacts with PA is unknown. This domain, made up of amino acids residues 1-263, is perched above the other three domains and is connected to the rest of the domains through an abrupt turn at the end of the last helix. Domain I consist of 12-helix bundle, packs against one face of a mixed four-stranded beta-sheet. | |||
<ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref> | <ref name=Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC>PMID: 11700563</ref> | ||