Amyloid beta: Difference between revisions
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Amyloid beta generates reactive oxygen species and induces oxidative stress and inflammation. When complexed with Cu(II) amyloid beta becomes a moderate oxidant that is capable to creating hydrogen peroxide in the presence of air and a reducing agent (such as ascorbate).<ref name="alz" /> | Amyloid beta generates reactive oxygen species and induces oxidative stress and inflammation. When complexed with Cu(II) amyloid beta becomes a moderate oxidant that is capable to creating hydrogen peroxide in the presence of air and a reducing agent (such as ascorbate).<ref name="alz" /> | ||
'''Toxicity in the Vasculature''' | |||
A build up of amyloid beta results in the oxidative stress, caspase activation, mitochondrial dysfunction and DNA damage. Once amyloid beta produces superoxide it can react with nitrogen oxide and cause vasoconstriction, decreasing the blood supply to the brain.<ref name="alz" /> | |||
'''Pore Formation''' | '''Pore Formation''' | ||