Angiotensin-Converting Enzyme: Difference between revisions
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<StructureSection load='1o8a' size='500' side='right' scene='Angiotensin-Converting_Enzyme/Ace_opening/1' caption=''> | |||
==Biological Role== | ==Biological Role== | ||
[[Image: Renin_system.png|470px|left|thumb| Renin-Angiotensin-Aldosterone System Schematic]] | [[Image: Renin_system.png|470px|left|thumb| Renin-Angiotensin-Aldosterone System Schematic]] | ||
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The C-Domain active site is strongly activated by chloride ion.<ref> PMID:7794265</ref> Two buried chloride ions are found in the ACE1 crystal structure. The first is about 21 angstroms from the zinc ion and is<scene name='Angiotensin-Converting_Enzyme/Chlorine_1/1'> bound to Arg 489, Arg 186, Trp 485 </scene>and is surrounded by a hydrophobic shell of four tryptophans. The second chloride ion is located <scene name='Angiotensin-Converting_Enzyme/Chlorine_2/3'>10 angstroms away from the zinc ion and is bound to Arg 522 and Tyr 224</scene>. It is believed that the first chloride ion stabilizes the active ACE1 structure. The primary ligand for the second chloride ion, <scene name='Angiotensin-Converting_Enzyme/Chlorine_2/2'>namely Arg 522 is located on helix 17 along with residues Tyr 520 and Tyr 523</scene> both of which are found in the active site. <ref name="Natesh"/> | The C-Domain active site is strongly activated by chloride ion.<ref> PMID:7794265</ref> Two buried chloride ions are found in the ACE1 crystal structure. The first is about 21 angstroms from the zinc ion and is<scene name='Angiotensin-Converting_Enzyme/Chlorine_1/1'> bound to Arg 489, Arg 186, Trp 485 </scene>and is surrounded by a hydrophobic shell of four tryptophans. The second chloride ion is located <scene name='Angiotensin-Converting_Enzyme/Chlorine_2/3'>10 angstroms away from the zinc ion and is bound to Arg 522 and Tyr 224</scene>. It is believed that the first chloride ion stabilizes the active ACE1 structure. The primary ligand for the second chloride ion, <scene name='Angiotensin-Converting_Enzyme/Chlorine_2/2'>namely Arg 522 is located on helix 17 along with residues Tyr 520 and Tyr 523</scene> both of which are found in the active site. <ref name="Natesh"/> | ||
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==Medical Implications== | ==Medical Implications== | ||