1w9b: Difference between revisions
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==Overview== | ==Overview== | ||
Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to | Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Sinapis alba]] | [[Category: Sinapis alba]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferred entry: 3 | [[Category: Transferred entry: 3 2.1 147]] | ||
[[Category: Arzt, S.]] | [[Category: Arzt, S.]] | ||
[[Category: Bourderioux, A.]] | [[Category: Bourderioux, A.]] | ||
[[Category: Burmeister, W | [[Category: Burmeister, W P.]] | ||
[[Category: Cottaz, S.]] | [[Category: Cottaz, S.]] | ||
[[Category: Gueyrard, D.]] | [[Category: Gueyrard, D.]] | ||
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[[Category: thiohydroximate]] | [[Category: thiohydroximate]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:48 2008'' | ||