Pertussis Toxin-ATP Complex: Difference between revisions

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Jonathan Tringali, Jaime Prilusky, Michal Harel

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 ==Treatment==
-Early treatment of pertussis is the only effective way to treat the bacterial infection.  If treatment for pertussis is started early in the course of illness during the 1 to 2 weeks before severe coughing occurs, the symptoms may be lessened.  If the diagnosed to late, antibiotics will not alter the course of the illness since the bacteria is already producing the PT toxin.  The preferred antibiotics are [http://en.wikipedia.org/wiki/Erythromycin Erythromycin], [http://en.wikipedia.org/wiki/Clarithromycin Clarithromycin], and [http://en.wikipedia.org/wiki/Azithromycin Azithromycin].
+Early treatment of pertussis is the only effective way to treat the bacterial infection.  If treatment for pertussis is started early in the course of illness during the 1 to 2 weeks before severe coughing occurs, the symptoms may be lessened.  The preferred antibiotics are [http://en.wikipedia.org/wiki/Erythromycin Erythromycin], [http://en.wikipedia.org/wiki/Clarithromycin Clarithromycin], and [http://en.wikipedia.org/wiki/Azithromycin Azithromycin].<ref name=Altunaiji>PMID: 17636756</ref> If the diagnosed to late, antibiotics will not alter the course of the illness since the bacteria is already producing the PT toxin.
 The primary method of prevention for pertussis is [http://en.wikipedia.org/wiki/Vaccination vaccination].  The [http://en.wikipedia.org/wiki/DPT_vaccine DTaP vaccine] vaccine is used and this vaccine is composed of diphtheria, tetanus, and pertussis.  The pertussis component is acellular; this acellular component are selected antigens (inactivated pertussis toxin (toxoid) and filamentous hemagglutinin) of pertussis that induces [http://en.wikipedia.org/wiki/Adaptive_immune_system adaptive immunity].