2j34: Difference between revisions

Revision as of 18:18, 30 October 2007

CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX

OverviewOverview

Torsional scans of sulfonamide S-C bonds in small model systems of a, series of arylsulfonamide factor Xa inhibitors were performed in order to, investigate if conformational effects can help to rationalise the observed, SAR. Computational results were in good agreement with the experimental, data indicating that the sulfonamide conformation plays an important role, in determining the activity in this particular series of factor Xa, inhibitors.

About this StructureAbout this Structure

2J34 is a [Single protein] structure of sequence from [Homo sapiens] with CA and GS6 as [ligands]. Active as [Coagulation factor Xa], with EC number [3.4.21.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors., Senger S, Convery MA, Chan C, Watson NS, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192

Page seeded by OCA on Tue Oct 30 17:23:01 2007

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

Revision as of 13:33, 30 October 2007 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits No edit summary ← Older edit		Revision as of 18:18, 30 October 2007 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits No edit summary Newer edit →
Line 35:		Line 35:
	[[Category: zymogen]]		[[Category: zymogen]]

	''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:38:11 2007''		''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:23:01 2007''