Sandbox 250: Difference between revisions

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Joel L. Sussman, Allison Granberry, Jaime Prilusky

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 . Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death.
-[[Image:New_Schematic_AChE_Fas.JPG|left|thumb|alt= Alt text| Figure 4. AChE/FAS-II
+[[Image:New_Schematic_AChE_Fas.JPG|left|thumb|alt= Alt text| AChE-fasciculin-2 complex. (a) A side view of the complex, illustrating the geometric complementarity of the two interacting proteins. AChE is presented as a yellow surface and fasciculin-2 as a blues ribbon. (b) A front view of both interacting proteins, presented separately as surfaces colored by electrostatic potential (blue is positive, white is neutral, and red is negative). To create this view, both proteins were rotated 90º compared to their position in a, AChE to the right and fasciculin to the left. The electrostatic compatibility between the two proteins is clear; The positively charged part of fasciculin matches the entrance to AChE's binding site, which is negatively charged.|500px]]
-(a) A side view of the interaction between FAS-II, colored cyan, and AChE, colored yellow.
-(b) An illustration of the electrostatic complementarity between FAS-II, to the left, and AChE, to the right. Each protein is colored according to their electrostatic potential: the red region is highly negative, the blue region is highly positive and the white region is neutral. Each of these views was rotated 90˚ relative to that of Figure 4.(a). It is interaction of the positive region of FAS-II and the highly negative region of gorge of AChE that provides the basis of long range attraction.  |500px]]
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