Antithrombin: Difference between revisions
Michal Harel (talk | contribs) New page: '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied gly... |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1tb6| PDB=1tb6 | SIZE=400| SCENE= |right|CAPTION=Antithrombin complex with thrombin and heparin polysaccharide, [[1tb6]] }} | |||
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. | ||
{{TOC limit|limit=2}} | |||
==3D structures of antithrombin== | ==3D structures of antithrombin== | ||
| Line 37: | Line 40: | ||
[[3kcg]] - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide | [[3kcg]] - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide | ||
[[Category:Topic Page]] | |||
Revision as of 22:32, 26 September 2011
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. A-AT contains 4 occupied glycosylation sites and is found in blood palsma. B-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interactin of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation.
3D structures of antithrombin3D structures of antithrombin
1att – AT-III – bovine
1e05 - ha-AT-III
1e04 – hb-AT-III
1dzg, 1oyh, 1t1f, 2beh, 2b4x, 2hij - hAT-III (mutant)
Antithrombin binary complexesAntithrombin binary complexes
1azx, 1nq9, 3evj – hAT + heparin pentasaccharide
1e03 – ha-AT-III + heparin pentasaccharide
1dzh - hAT-III (mutant) + fluorescein
2gd4 - hAT-III (mutant) + coagulation factor X
1br8, 1jvq, 1lk6, 1r1l – hAT-III + peptide
Antithrombin ternary complexesAntithrombin ternary complexes
1sr5 - hAT-III + prothrombin + heparin heptasaccharide
1tb6 - hAT-III (mutant) + thrombin + heparin polysaccharide
2b5t - AT-III (mutant) + thrombin (mutant) + heparin polysaccharide
3kcg - hAT-III (mutant) + coagulation factor IXa + heparin pentasaccharide