Aricept Complexed with Acetylcholinesterase: Difference between revisions
Eran Hodis (talk | contribs) No edit summary |
Eran Hodis (talk | contribs) |
||
| Line 7: | Line 7: | ||
==Results== | ==Results== | ||
The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/3'>unique orientation</scene>, along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/1'>W84</scene>) of the, active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/1'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only indirectly via solvent molecules. | The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/3'>unique orientation</scene>, along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/1'>W84</scene>) of the, active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/1'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only <scene name='1eve/E2020_interaction/1'>indirectly via solvent molecules</scene>. | ||
==Conclusions== | ==Conclusions== | ||