365d: Difference between revisions

Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 4: / Line 4: @@
 ==Overview==
-Small molecules that target specific DNA sequences offer a potentially, general approach for the regulation of gene expression. Pyrrole-imidazole, polyamides represent the only class of synthetic small molecules that can, bind predetermined DNA sequences with affinities and specificities, comparable to DNA binding proteins. Antiparallel side-by-side pairings of, two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C, from C.G, and both from A.T/T.A base pairs. A high resolution X-ray, crystal structure of a four-ring pyrrole-imidazole polyamide specifically, bound as a dimer to a six-base pair predetermined DNA site reveals a, structural framework of hydrogen bonds and interactions with the walls of, the minor groove that underlies the pairing rules for DNA recognition.
+Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.
 ==About this Structure==
@@ Line 12: / Line 12: @@
 Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461074 9461074]
 [[Category: Protein complex]]
-[[Category: Baird, E.E.]]
+[[Category: Baird, E E.]]
-[[Category: Dervan, P.B.]]
+[[Category: Dervan, P B.]]
-[[Category: Kielkopf, C.L.]]
+[[Category: Kielkopf, C L.]]
-[[Category: Rees, D.C.]]
+[[Category: Rees, D C.]]
 [[Category: IIP]]
 [[Category: b-dna]]
@@ Line 21: / Line 21: @@
 [[Category: modified]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:36:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:20 2008''