P53R2: Difference between revisions
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{{STRUCTURE_3hf1| PDB=3hf1 | SIZE=400| SCENE=P53R2/P53r2/3 |right|CAPTION=p53R2 complex with Fe and sulfate ions, [[3hf1]] }} | {{STRUCTURE_3hf1| PDB=3hf1 | SIZE=400| SCENE=P53R2/P53r2/3 |right|CAPTION=p53R2 complex with Fe and sulfate ions, [[3hf1]] }} | ||
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p53R2 is included in the RR class I which are characterized by a tyrosyl radical coupled with diiron cluster. A protein which possess tyrosyl radicals with binuclear center is known to have an oxidative or a reductive effect. So for the researchers Lijun Xue et al. <ref>PMID:16488986</ref> it raises the question of the redox properties of p53R2. They found that p53R2 is an antioxidant which can scavenge H2O2. The mitochondrial membrane is sensible to oxidative damage. H2O2 is a reactive oxygen specie (ROS) which can act on cellular growth and survival and is involved in pathogenesis like cancer. p53R2 prevents the loss of mitochondrial membrane by scavenging H2O2. This process protects cells by maintaining their genomic integrity and prevent from cancer. | p53R2 is included in the RR class I which are characterized by a tyrosyl radical coupled with diiron cluster. A protein which possess tyrosyl radicals with binuclear center is known to have an oxidative or a reductive effect. So for the researchers Lijun Xue et al. <ref>PMID:16488986</ref> it raises the question of the redox properties of p53R2. They found that p53R2 is an antioxidant which can scavenge H2O2. The mitochondrial membrane is sensible to oxidative damage. H2O2 is a reactive oxygen specie (ROS) which can act on cellular growth and survival and is involved in pathogenesis like cancer. p53R2 prevents the loss of mitochondrial membrane by scavenging H2O2. This process protects cells by maintaining their genomic integrity and prevent from cancer. | ||
==3D structures of ribonucleotide reductase== | |||
[[Ribonucleotide reductase]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||