Neuroligin: Difference between revisions
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[[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]] | [[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]] | ||
{{ | {{STRUCTURE_3b3q| PDB=3b3q | SIZE=400| SCENE= |right|CAPTION=Human neuroligin 4 complex with glycerol, citrate, phosphate,, Na and Cl ions [[3be3q]] }} | ||
[[Neuroligin|Neuroligins]] (NLGN) are a family of postsynaptic proteins which bind to the presynaptic [[Neurexin]] (NRXN) to form a complex which attaches neurons. The NLGN family contains 4 members which are numbered 1 to 4. The images at the left and at the right correspond to one representative NLGN, ''i.e.'' the crystal structure of human Neuroligin ([[3be8]]). | [[Neuroligin|Neuroligins]] (NLGN) are a family of postsynaptic proteins which bind to the presynaptic [[Neurexin]] (NRXN) to form a complex which attaches neurons. The NLGN family contains 4 members which are numbered 1 to 4. The images at the left and at the right correspond to one representative NLGN, ''i.e.'' the crystal structure of human Neuroligin ([[3be8]]). | ||
Revision as of 12:52, 8 November 2012
Neuroligins (NLGN) are a family of postsynaptic proteins which bind to the presynaptic Neurexin (NRXN) to form a complex which attaches neurons. The NLGN family contains 4 members which are numbered 1 to 4. The images at the left and at the right correspond to one representative NLGN, i.e. the crystal structure of human Neuroligin (3be8).
For Structural Analysis of Neuroligin, See: Neuroligin-Neurexin Interaction
3D Structures of Neuroligin3D Structures of Neuroligin
NLGNNLGN
3bl8 - mNLGN-2 cholinesterase domain – mouse
3be8 - hNLGN-4 cholinesterase domain – human
3bix - rNLGN-1 cholinesterase domain - rat
NLGN+NRXNNLGN+NRXN
2xb6, 2wqz – hNLGN-4 cholinesterase domain+NRXN-1β LNS domain
3b3q - mNLGN-4 cholinesterase domain+NRXN-1β LNS domain
3biw - rNLGN-1 cholinesterase domain+NRXN-1β LNS domain