Molecular Playground/ERMan1

ERMan1ERMan1

Alpha-mannosidases I(ERMan1) is a human protein that resides in the endoplasmic reticulum(ER). ERMan1 is a member of the class 1 glycosylhydrolase family 47 group proteins and sports a Tim-barrel fold. Asparagine(N)-linked glycans are common covalent modifiers in the ER that aid in protein folding and trafficking. ERMan1 trims N-linked glycans to target a misfolded protein for degradation. The slow acting kinetics of ERMan1 have been proposed to act as a timer for protein degradation, creating a discrete window for protein folding followed by degradation if the substrate protein cannot reach the native state.

spinqualitylabelsall models PDB ID 1x9d Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Human α-mannosidase class I complex with mannopyranoside, sulfate, 1,4-butanediol, Ca+2 ion, 1x9d
Ligands:	, , ,
Gene:	MAN1B1 (Homo sapiens)
Activity:	Mannosyl-oligosaccharide 1,2-alpha-mannosidase, with EC number 3.2.1.113
Related:	1fmi
Structural annotation: Resources: CATH : 1X9Da00 InterPro : Ipr001382 Pfam : PF01532 UniProt : Q9UKM7
Functional annotation: Cellular component: membrane endoplasmic reticulum integral to membrane membrane fraction Biological process: oligosaccharide metabolic process protein amino acid N-linked glycosylation metabolic process Molecular function: hydrolase activity hydrolase activity, acting on glycosyl bonds calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

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3D structures of mannosidases3D structures of mannosidases

Mannosidase

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