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{{STRUCTURE_2lez| PDB=2lez | SCENE= }} | |||
===Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.<ref>PMID:12864852</ref> <ref>PMID:15987736</ref> <ref>PMID:16938850</ref> | |||
==About this Structure== | |||
[[2lez]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEZ OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | |||
[[Category: Arrowsmith, C.]] | |||
[[Category: Daniels, C.]] | |||
[[Category: Garcia, M.]] | |||
[[Category: Houliston, S.]] | |||
[[Category: Lemak, A.]] | |||
[[Category: Montelione, G T.]] | |||
[[Category: NESG, Northeast Structural Genomics Consortium.]] | |||
[[Category: Savchenko, A.]] | |||
[[Category: Yee, A.]] | |||
[[Category: Bacterial effector]] | |||
[[Category: Nesg]] | |||
[[Category: Northeast structural genomics consortium]] | |||
[[Category: Signaling protein]] | |||
[[Category: Structural genomic]] | |||
[[Category: Virulence factor]] | |||
Revision as of 10:59, 16 May 2013
Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318aSolution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a
FunctionFunction
[PIPB2_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.[1] [2] [3]
About this StructureAbout this Structure
2lez is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full experimental information is available from OCA.
ReferenceReference
- ↑ Knodler LA, Vallance BA, Hensel M, Jackel D, Finlay BB, Steele-Mortimer O. Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. Mol Microbiol. 2003 Aug;49(3):685-704. PMID:12864852
- ↑ Knodler LA, Steele-Mortimer O. The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate Sif extension. Mol Biol Cell. 2005 Sep;16(9):4108-23. Epub 2005 Jun 29. PMID:15987736 doi:10.1091/mbc.E05-04-0367
- ↑ Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S. The Salmonella effector protein PipB2 is a linker for kinesin-1. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13497-502. Epub 2006 Aug 25. PMID:16938850 doi:10.1073/pnas.0605443103
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OCACategories:
- Salmonella enterica subsp. enterica serovar typhimurium
- Arrowsmith, C.
- Daniels, C.
- Garcia, M.
- Houliston, S.
- Lemak, A.
- Montelione, G T.
- NESG, Northeast Structural Genomics Consortium.
- Savchenko, A.
- Yee, A.
- Bacterial effector
- Nesg
- Northeast structural genomics consortium
- Signaling protein
- Structural genomic
- Virulence factor