Lactate Dehydrogenase: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jasper Small, David Canner, Ann Taylor, Michal Harel, Alexander Berchansky, Joel L. Sussman

@@ Line 32: / Line 32: @@
 As the mechanism is one of equilibrium, There appears to be no regulation specifically designed for lactate dehydrogenase, instead it is dependent on the activation of anaerobic reparation and the presence of pyruvate and NADH, or lactate and NAD+.
+==3D structures of lactate dehydrogenase==
+[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
+[[2xxe]] – TtL-LDH (mutant) <BR />
+[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
+[[2zqy]], [[2zqz]], [[1llc]] – L-LDH – ''Lactobacillus casei''<BR />
+[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
+[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
+[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
+[[2frm]] – CpLDH – ''Cryptosporidium parvum''<BR />
+[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
+[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
+[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
+[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
+[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
+[[2ldx]] – C4-LDH - mouse
+===LDH binary complex===
+[[2ydn]] – PfL-LDH + bicine<BR />
+[[1cet]] - PfL-LDH + chloroquine<BR />
+[[1t2c]] - PfL-LDH + NAD<BR />
+[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
+[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
+[[2a92]] – PvL-LDH + NAD – ''Plasmodium vivax'' <BR />
+[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
+[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
+[[2xxb]] – TtL-LDH (mutant) + AMP
+===L-LDH ternary complex with inhibitor===
+[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
+[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
+[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
+[[1ldg]] - PfL-LDH + oxamate + NAD<BR />
+[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
+[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
+[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
+[[3h3f]] – L-LDH A chain + oxamate + NAD – rabbit<BR />
+[[2fnz]] - CpLDH + oxamate + NAD<BR />
+[[1t2f]] - hL-LDH B chain + azole derivative + NAD – human<BR />
+[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
+[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
+[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
+[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
+[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
+[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
+[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
+===L-LDH ternary complex with reactants===
+[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
+[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
+[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
+[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
+[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
+[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
+[[2fn7]] - CpLDH + lactate + NAD<BR />
+[[2ewd]] - CpLDH + pyruvate + NAD-analog<br />
+[[2fm3]] - CpLDH + pyruvate + NAD<BR />
+[[5ldh]] - pLDH + citrate + NAD-analog<br />
+[[3ldh]] - sdLDH + pyruvate + NAD<BR />
+===D-LDH===
+[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
+[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
+[[1j4a]] - LdD-LDH + sulfate<BR />
+[[1f0x]] – D-LDH + FAD – ''Escherichia coli''<BR />
+[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''
+===L-LDH II===
+[[1x0a]], [[1vbi]] – TtL-LDH II
 ==Additional Information==