Interleukin: Difference between revisions

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==3D structures of factor IX==
==3D structures of factor IX==
===IL-1 α===
[[2ila]] - hIL-1 α - human<BR />
[[2kki]] - hIL-1 α residues 121-271 <BR />
[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR<BR />
===IL-1 β===
[[2wry]] - cIL-1 β – chicken<BR />
[[3nj5]] – cIL-1 β (mutant) <BR />
[[2nvh]], [[9ilb]], [[1iob]], [[5i1b]], [[2i1b]], [[4i1b]], [[1i1b]] - hIL-1 β
[[1tp0]], [[1t4q]], [[1too]], [[1twe]], [[1twm]], [[1s0l]], [[1l2h]], [[1hib]], [[21bi]], [[31bi]], [[41bi]] - hIL-1 β (mutant) <BR />
[[6i1b]], [[7i1b]] - hIL-1 β]] - NMR<BR />
[[3ltq]] - hIL-1 β residues 117-269 <BR />
[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
[[2kh2]] - hIL-1 β + SCFV]] - NMR<BR />
[[1md6]] – mIL-1F5 – mouse<BR />
[[2mib]], [[8i1b]] - mIL-1 β
===IL-2===
[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
[[1irl]] – hIL-2 (mutant)]] - NMR<BR />
2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ<BR />
[[1z92]] - hIL-2 + IL-2 receptor α<BR />
[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
===IL-3===
[[1jli]] – hIL-3 (mutant) – NMR<BR />
===IL-4===
[[2b8u]], [[1hik]], [[2int]] – hIL-4<BR />
[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
===IL-5===
[[1hul]] – hIL-5<BR />
[[3b5k]] – mIL-5
===IL-6===
[[1alu]] – hIL-6<BR />
[[1il6]], [[2il6]] – hIL-6]] - NMR<BR />
[[1p9m]] - hIL-6 + IL-6 receptor α and β
===IL-7===
[[3di2]], [[3di3]] - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
===IL-8===
[[3il8]] – hIL-8<BR />
[[1il8]], [[2il8]] – hIL-8]] - NMR<BR />
[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
[[1ikl]], [[1ikm]] - hIL-8 (mutant)]] - NMR<BR />
[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
===IL-10===
[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
===IL-10 viral===
[[1vlk]] - hvIL-10 residues 26-170]] - human herpesvirus 4<BR />
[[1y6m]] - hvIL-10 residues 26-170 + IL-10 receptor α <BR />
[[1y6n]] - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α <BR />
[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
[[1lk3]] - hvIL-10 residues 26-175 + antibody
===IL-12===
[[1f45]] - hIL-12 α and β (mutant) <BR />
[[1f42]] - hIL-12 β P40 domain<BR />
[[3hmx]] - hIL-12 α and β+ antibody
===IL-13===
[[1ijz]], [[1ik0]] – hIL-13 – NMR<BR />
[[1ga3]] - hIL-13 residues 21-132]] - NMR<BR />
[[3l5w]], [[3l5x]], [[3l5y]], [[3g6d]] - hIL-13 residues 35-146 + antibody<BR />
[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
[[3bpo]] - hIL-13 + IL-4 receptor α + IL-13 receptor α
===IL-15===
[[2xqb]] – hIL-15 + antibody<BR />
[[2psm]], [[2z3q]], [[2z3r]] - hIL-15 + IL-15 receptor α
===IL-16===
[[1i16]] – hIL-16]] - NMR<BR />
[[1x6d]] – hIL-16 PDZ domain – NMR<BR />
===IL-17===
[[2vxs]] - hIL-17A residues 20-255 + antibody<BR />
[[1jpy]] – hIL-17F<BR />
[[3jvf]] - hIL-17F + IL-17 receptor α
===IL-18===
[[1j0s]] – hIL-18]] - NMR<BR />
[[2vxt]] - hIL-18 (mutant) + antibody<BR />
[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein
===IL-19===
[[1n1f – hIL-19
===IL-21===
[[2oqp – hIL-21 – NMR<BR />
===IL-22===
[[1ykb]], [[1m4r]] – hIL-22<BR />
[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1
===IL-23===
[[3d87]] - hIL-23 α<BR />
[[3d85]] - hIL-23 α + antibody<BR />
[[3duh]] - hIL-23 α + hIL-12 β
===IL-33===
[[2kll]] - hIL-33 residues 110-270 - NMR<BR />




   [[Category:Topic Page]]
   [[Category:Topic Page]]

Revision as of 12:47, 6 July 2011

Template:STRUCTURE 2nvh

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers. For some detailed interleukins see Interleukin-10 and Interleukin-15.

3D structures of factor IX3D structures of factor IX

IL-1 αIL-1 α

2ila - hIL-1 α - human
2kki - hIL-1 α residues 121-271
2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR

IL-1 βIL-1 β

2wry - cIL-1 β – chicken
3nj5 – cIL-1 β (mutant)
2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β 1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)
6i1b, 7i1b - hIL-1 β]] - NMR
3ltq - hIL-1 β residues 117-269
3pok - hIL-1 β residues 117-269 (mutant)
1itb - hIL-1 β + IL-1 receptor 1 extracellular domain
3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein
2kh2 - hIL-1 β + SCFV]] - NMR
1md6 – mIL-1F5 – mouse
2mib, 8i1b - mIL-1 β

IL-2IL-2

1m47, 1m4c, 3ink – hIL-2
1irl – hIL-2 (mutant)]] - NMR
2erj]], 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ
1z92 - hIL-2 + IL-2 receptor α
1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor
1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor

IL-3IL-3

1jli – hIL-3 (mutant) – NMR

IL-4IL-4

2b8u, 1hik, 2int – hIL-4
2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR
2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant)
1iar - hIL-4 + IL-4 receptor α (mutant)
3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ
3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α

IL-5IL-5

1hul – hIL-5
3b5k – mIL-5

IL-6IL-6

1alu – hIL-6
1il6, 2il6 – hIL-6]] - NMR
1p9m - hIL-6 + IL-6 receptor α and β

IL-7IL-7

3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain

IL-8IL-8

3il8 – hIL-8
1il8, 2il8 – hIL-8]] - NMR
1qe6, 1icw – hIL-8 (mutant)
1ikl, 1ikm - hIL-8 (mutant)]] - NMR
1ilp, 1ilq - hIL-8 + IL-8 receptor peptide

IL-10IL-10

2h24, 1inr, 2ilk, 1ilk – hIL-10
1j7v – hIL-10 + IL-10 receptor α (mutant)
1y6k - hIL-10 residues 19-178 + IL-10 receptor α

IL-10 viralIL-10 viral

1vlk - hvIL-10 residues 26-170]] - human herpesvirus 4
1y6m - hvIL-10 residues 26-170 + IL-10 receptor α
1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α
1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5
1lk3 - hvIL-10 residues 26-175 + antibody

IL-12IL-12

1f45 - hIL-12 α and β (mutant)
1f42 - hIL-12 β P40 domain
3hmx - hIL-12 α and β+ antibody

IL-13IL-13

1ijz, 1ik0 – hIL-13 – NMR
1ga3 - hIL-13 residues 21-132]] - NMR
3l5w, 3l5x, 3l5y, 3g6d - hIL-13 residues 35-146 + antibody
3lb6 - hIL-13 + IL-13 receptor α2
3bpo - hIL-13 + IL-4 receptor α + IL-13 receptor α

IL-15IL-15

2xqb – hIL-15 + antibody
2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α

IL-16IL-16

1i16 – hIL-16]] - NMR
1x6d – hIL-16 PDZ domain – NMR

IL-17IL-17

2vxs - hIL-17A residues 20-255 + antibody
1jpy – hIL-17F
3jvf - hIL-17F + IL-17 receptor α

IL-18IL-18

1j0s – hIL-18]] - NMR
2vxt - hIL-18 (mutant) + antibody
3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein

IL-19IL-19

[[1n1f – hIL-19

IL-21IL-21

[[2oqp – hIL-21 – NMR

IL-22IL-22

1ykb, 1m4r – hIL-22
3g9v - hIL-22 residues 29-179 + IL-22 receptor α2
3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1

IL-23IL-23

3d87 - hIL-23 α
3d85 - hIL-23 α + antibody
3duh - hIL-23 α + hIL-12 β

IL-33IL-33

2kll - hIL-33 residues 110-270 - NMR

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky
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