2glw: Difference between revisions
New page: left|200px<br /><applet load="2glw" size="350" color="white" frame="true" align="right" spinBox="true" caption="2glw" /> '''The solution structure of PHS018 from pyroco... |
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==Overview== | ==Overview== | ||
The core of swapped-hairpin and double-psi beta barrels is formed by | The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Coles, M.]] | [[Category: Coles, M.]] | ||
[[Category: Hulko, M.]] | [[Category: Hulko, M.]] | ||
[[Category: Lupas, A | [[Category: Lupas, A N.]] | ||
[[Category: Martin, J.]] | [[Category: Martin, J.]] | ||
[[Category: Truffault, V.]] | [[Category: Truffault, V.]] | ||
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[[Category: rift barrel]] | [[Category: rift barrel]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:32:57 2008'' | ||
Revision as of 18:32, 21 February 2008
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The solution structure of PHS018 from pyrococcus horikoshii
OverviewOverview
The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
About this StructureAbout this Structure
2GLW is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
ReferenceReference
Common evolutionary origin of swapped-hairpin and double-psi beta barrels., Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN, Structure. 2006 Oct;14(10):1489-98. PMID:17027498
Page seeded by OCA on Thu Feb 21 17:32:57 2008