2gc8: Difference between revisions
New page: left|200px<br /><applet load="2gc8" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gc8, resolution 2.20Å" /> '''Structure of a Proli... |
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==Overview== | ==Overview== | ||
Through high throughput screening, substituted proline sulfonamide 6 was | Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity. The crystal structure of 6 and NS5b polymerase complex confirmed the binding near the active site region. The optimization approach and SAR are discussed in detail. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Chopra, R.]] | [[Category: Chopra, R.]] | ||
[[Category: Ciszewski, G.]] | [[Category: Ciszewski, G.]] | ||
[[Category: Curran, K | [[Category: Curran, K J.]] | ||
[[Category: Ellingboe, J | [[Category: Ellingboe, J W.]] | ||
[[Category: Feld, B.]] | [[Category: Feld, B.]] | ||
[[Category: Gopalsamy, A.]] | [[Category: Gopalsamy, A.]] | ||
[[Category: Howe, A | [[Category: Howe, A Y.]] | ||
[[Category: Krishnamurthy, G.]] | [[Category: Krishnamurthy, G.]] | ||
[[Category: Lim, K.]] | [[Category: Lim, K.]] | ||
[[Category: Mansour, T | [[Category: Mansour, T S.]] | ||
[[Category: Orlowski, M.]] | [[Category: Orlowski, M.]] | ||
[[Category: Shi, M.]] | [[Category: Shi, M.]] | ||
[[Category: Sukits, S | [[Category: Sukits, S F.]] | ||
[[Category: Svenson, K.]] | [[Category: Svenson, K.]] | ||
[[Category: connell, J | [[Category: connell, J O.]] | ||
[[Category: 885]] | [[Category: 885]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:30:16 2008'' | ||
