Triose Phosphate Isomerase: Difference between revisions
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One specific example of sequence homology is that of loop 6 and loop 7 residues, whose structural contributions are discussed above. In a sequence alignment of 133 TIM sequences, two highly conserved motifs are noticed. First, 114 sequences in loop 6 contain the PXW sequence family (where X is I,L or V in 112 sequences or otherwise a T or K). Secondly, loop 7 contains a highly conserved YGGS motif; however, this motif is only found when the N-terminal hinge contains tryptophan. | One specific example of sequence homology is that of loop 6 and loop 7 residues, whose structural contributions are discussed above. In a sequence alignment of 133 TIM sequences, two highly conserved motifs are noticed. First, 114 sequences in loop 6 contain the PXW sequence family (where X is I,L or V in 112 sequences or otherwise a T or K). Secondly, loop 7 contains a highly conserved YGGS motif; however, this motif is only found when the N-terminal hinge contains tryptophan. | ||
== | == 3D Structures of triose phosphate isomerase== | ||
[[1tim]], [[8tim]] - TIM - chicken<br /> | |||
[[1amk]] – TIM – ''Leishmania mexicana''<br /> | |||
[[2ypi]] - TIM + substrate analog - yeast<br /> | |||
[[2vom]] - hTIM (mutant) - human<br /> | |||
[[1wyi]] - hTIM<br /> | |||
[[1lyx]], [[1lzo]], [[1m7o]], [[1m7p]] – TIM + substrate analog – ''Plasmodium falciparum''<br /> | |||
[[2j27]] - TIM (mutant) -''Trypanosoma brucei '' | |||
===MonoTIM – stable monomeric variant of TIM=== | |||
[[2wsq]], [[2wsr]] – TbMonoTIM (mutant) | |||
== Additional Resources == | == Additional Resources == | ||