2ym8: Difference between revisions

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Revision as of 09:19, 11 January 2012

File:2ym8.png

Template:STRUCTURE 2ym8

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitorsCrystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Template:ABSTRACT PUBMED 22111927

About this StructureAbout this Structure

2ym8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}^{[xtra 3]}

↑ Reader JC, Matthews TP, Klair S, Cheung KM, Scanlon J, Proisy N, Addison G, Ellard J, Piton N, Taylor S, Cherry M, Fisher M, Boxall K, Burns S, Walton MI, Westwood IM, Hayes A, Eve P, Valenti M, de Haven Brandon A, Box G, van Montfort RL, Williams DH, Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I. Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. Epub 2011 Nov 23. PMID:22111927 doi:10.1021/jm2007326
↑ Matthews TP, Klair S, Burns S, Boxall K, Cherry M, Fisher M, Westwood IM, Walton MI, McHardy T, Cheung KM, Van Montfort R, Williams D, Aherne GW, Garrett MD, Reader J, Collins I. Identification of inhibitors of checkpoint kinase 1 through template screening. J Med Chem. 2009 Aug 13;52(15):4810-9. PMID:19572549 doi:10.1021/jm900314j
↑ Matthews TP, McHardy T, Klair S, Boxall K, Fisher M, Cherry M, Allen CE, Addison GJ, Ellard J, Aherne GW, Westwood IM, van Montfort R, Garrett MD, Reader JC, Collins I. Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4045-9. Epub 2010 May 27. PMID:20561787 doi:10.1016/j.bmcl.2010.05.096

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OCA

[1] Reader JC, Matthews TP, Klair S, Cheung KM, Scanlon J, Proisy N, Addison G, Ellard J, Piton N, Taylor S, Cherry M, Fisher M, Boxall K, Burns S, Walton MI, Westwood IM, Hayes A, Eve P, Valenti M, de Haven Brandon A, Box G, van Montfort RL, Williams DH, Aherne GW, Raynaud FI, Eccles SA, Garrett MD, Collins I. Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. Epub 2011 Nov 23. PMID:22111927 doi:10.1021/jm2007326

[2] Matthews TP, Klair S, Burns S, Boxall K, Cherry M, Fisher M, Westwood IM, Walton MI, McHardy T, Cheung KM, Van Montfort R, Williams D, Aherne GW, Garrett MD, Reader J, Collins I. Identification of inhibitors of checkpoint kinase 1 through template screening. J Med Chem. 2009 Aug 13;52(15):4810-9. PMID:19572549 doi:10.1021/jm900314j

[3] Matthews TP, McHardy T, Klair S, Boxall K, Fisher M, Cherry M, Allen CE, Addison GJ, Ellard J, Aherne GW, Westwood IM, van Montfort R, Garrett MD, Reader JC, Collins I. Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4045-9. Epub 2010 May 27. PMID:20561787 doi:10.1016/j.bmcl.2010.05.096

[xtra 1]

[xtra 2]

[xtra 3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2ym8.png|left|200px]]
-The entry 2ym8 is ON HOLD  until Paper Publication
+<!--
+The line below this paragraph, containing "STRUCTURE_2ym8", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_2ym8|  PDB=2ym8  |  SCENE=  }}
-Authors: Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.M.J., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., Cherry, M., Fisher, M., Boxall, K., Burns, S., Walton, M.I., Westwood, I.M., Hayes, A., Eve, P., Valenti, M., Brandon, A.H., Box, G., vanMontfort, R.L.M., Williams, D.H., Aherne, G.W., Raynaud, F.I., Eccles, S.E., Garrett, M.D., Collins, I.
+===Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors===
-Description: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_22111927}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 22111927 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_22111927}}
+==About this Structure==
+[[2ym8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YM8 OCA].
+==Reference==
+<ref group="xtra">PMID:022111927</ref><ref group="xtra">PMID:019572549</ref><ref group="xtra">PMID:020561787</ref><references group="xtra"/>
+[[Category: Homo sapiens]]
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Addison, G.]]
+[[Category: Aherne, G W.]]
+[[Category: Box, G.]]
+[[Category: Boxall, K.]]
+[[Category: Brandon, A H.]]
+[[Category: Burns, S.]]
+[[Category: Cherry, M.]]
+[[Category: Cheung, K M.J.]]
+[[Category: Collins, I.]]
+[[Category: Eccles, S A.]]
+[[Category: Ellard, J.]]
+[[Category: Eve, P.]]
+[[Category: Fisher, M.]]
+[[Category: Garrett, M D.]]
+[[Category: Hayes, A.]]
+[[Category: Klair, S.]]
+[[Category: Matthews, T P.]]
+[[Category: Piton, N.]]
+[[Category: Proisy, N.]]
+[[Category: Raynaud, F I.]]
+[[Category: Reader, J C.]]
+[[Category: Scanlon, J.]]
+[[Category: Taylor, S.]]
+[[Category: Valenti, M.]]
+[[Category: Vanmontfort, R L.M.]]
+[[Category: Walton, M I.]]
+[[Category: Westwood, I M.]]
+[[Category: Williams, D H.]]
+[[Category: Dna repair]]
+[[Category: Serine/threonine kinase]]
+[[Category: Transferase]]

2ym8: Difference between revisions

Revision as of 09:19, 11 January 2012

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitorsCrystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

About this StructureAbout this Structure

ReferenceReference

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